Lunchlezing CRISPR/Cas9

Project Info

Project Description

It’s time for the first Lunch Lecture of S.V.N.B. Hooke this year! It’ll be on forthcoming Thursday 20th of October. Stan Brouns will visit us to talk about the revolutionary technique CRISPR/Cas9. This technique has a lot of potential, but it creates some ethical dilemmas as well. There were 2 TED Talks about CRISPR/Cas9 quite recently and now Stan Brouns will enlighten us about this technique.

From understanding CRISPR biology to CRISPR 2.0 applications

The CRISPR immune system protects bacteria and archaea from invading viruses and plasmids. Immunity depends on protein complexes that use small RNA molecules to find matching viral or plasmid DNA. I will show how viruses escape immunity by mutating their DNA, and how a mechanism called priming takes care of these escaped viruses and will quickly update the memory of the immune system. All of these insights into the biology of CRISPR has led to some of the most revolutionary molecular genetics tools to date, with Cas9 being the most well known example. I will highlight some new CRISPR tools for genome engineering approaches to edit genomes and to knockdown gene expression.

Stan J.J. Brouns

Department of Bionanoscience, Kavli institute of Nanoscience, Delft University of Technology, Netherlands

Laboratory of Microbiology, Wageningen University, Netherlands